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Effect of Virus Dose and Nonoxynol‐9 on the Genital Transmission of SIV in Rhesus Macaques
Author(s) -
Miller Christopher J.,
Alexander Nancy J.,
Sutjipto Suganto,
Joye Steven M.,
Hendrickx Andrew G.,
Jennings Myra,
Marx Preston A.
Publication year - 1990
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1990.tb00445.x
Subject(s) - viremia , spermicide , virology , simian immunodeficiency virus , transmission (telecommunications) , virus , rhesus macaque , sexual transmission , biology , inoculation , penis , immunology , microbicide , medicine , anatomy , population , research methodology , human immunodeficiency virus (hiv) , environmental health , family planning , electrical engineering , engineering
One inoculation of cell‐free SIV MAC ‐ (50 TC1D 50 ) caused persistent viremia in nine of 13 female rhesus macaques inoculated intravaginally. Persistent viremia was produced in two of four male rhesus macaques by twice placing cell‐free SIV MAC (50 TCID 50 ) onto the skin and urethral os of the penis. Placing a spermicide containing nonoxynol‐9 into the vaginal canal prior to repeated intravaginal inoculations of SIV prevented transmission of the virus in three of six female rhesus macaques.