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Antibody‐Dependent Enhancement of SIV Infection: Further Characterization and Cross Reactivity Between Macaque and Sooty Mangabey Isolates
Author(s) -
Montefiori David C.,
Robinson W. Edward,
Hirsch Vanessa M.,
Modliszewski Ann,
Mitchell William M.,
Johnson Philip R.
Publication year - 1990
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1990.tb00433.x
Subject(s) - simian immunodeficiency virus , virology , rhesus macaque , antibody , biology , titer , macaque , clone (java method) , immunology , antibody titer , virus , complement (music) , genetics , phenotype , dna , paleontology , complementation , gene
Plasma from four rhesus macaques (Macaca mulatta), of which two were experimentally infected with the simian immunodeficiency virus (SIV) isolate SIVmac251, one with isolate SIVsmF236, and another with a SIVsmF236 molecular clone, SIVsmH‐4, enhanced SIVmac infection of MT‐2 cells. In addition to SIV‐positive plasma, infection‐enhancement required complement, CD4, and CR2. Titers of infection‐enhancing antibodies appeared to correlate with disease progression. The MT‐2/SIVmac251 system should be useful in future studies of complement‐mediated, antibody‐dependent enhancement of macaque and sooty mangabey SIV isolates.