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Inhibition of SIV/SMM Replication In Vitro by CD8 + Cells From SIV/SMM Infected Seropositive Clinically Asymptomatic Sooty Mangabeys
Author(s) -
Powell Jonathan D.,
YehudaCohen Tamar,
Villinger Francois,
McClure Harold M.,
Sell Kenneth W.,
AhmedAnsari Aftab
Publication year - 1990
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1990.tb00431.x
Subject(s) - in vitro , virology , simian immunodeficiency virus , biology , viral replication , cd8 , asymptomatic , cytotoxic t cell , virus , antigen , immunology , medicine , genetics , pathology
Several investigators have demonstrated the ability of CD8 + T cells from HIV‐1 infected humans and SIV infected rhesus macaques to inhibit viral replication in vitro. In this report we show that CD8 + cells from naturally SIV infected sooty mangabeys also have the ability to inhibit viral replication in vitro. In addition, initial experiments which seek to elucidate the mechanism and antigen specificity of CD8‐mediated suppression are described.