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Maternal Transmission of Type D Simian Retrovirus (SRV‐2) in Pigtailed Macaques
Author(s) -
Tsai C.C.,
Follis K.E.,
Snyder K.,
Windsor S.,
Thouless M.E.,
Kuller L.,
Morton W.R.
Publication year - 1990
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1990.tb00428.x
Subject(s) - virology , simian , transmission (telecommunications) , retrovirus , biology , type (biology) , virus , computer science , telecommunications , ecology
Pregnant macaques were used as a natural model for maternal‐infant transmission of SRV‐2 retrovirus. Fifty‐one pregnant females were placed into one of four virus/antibody groups. Nonviremic mothers produced 100% virus‐negative offspring at birth. In contrast, viremic mothers produced offspring which were 17% virus‐negative and 83% virus‐positive at birth. SRV‐2 infection occurred principally in utero by the transplacental route. Infants born to viremic mothers exhibited low birth weight, prematurity, high perinatal death, and increased incidence of SAIDS.