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Mesenchymoproliferative Disorders (MPD) in Simian AIDS Associated With SRV‐2 Infection
Author(s) -
Tsai Cheng C.,
Tsai CheChung,
Roodman Stanford T.,
Woon MingDar
Publication year - 1990
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1990.tb00427.x
Subject(s) - simian , virology , medicine , immunology , virus
We have observed several mesenchymal proliferative disorders (MPD) in macaques with SA1DS associated with SRV‐2 infection. Retroperitoneal and subcutaneous fibromatosis, progressive fibrovascular proliferation, mimicking Kaposi's sarcoma, were seen in 165 macaques. Three obliterative fibrointimal proliferative arteriopathies and one congenital pulmonary sequestration with extensive MPD were observed in SRV‐2 positive monkeys. Continuous cell lines were established and SRV‐2 was identified in all tissues and cell lines. Immunophenotyping of the cultured cells showed heterogeneous mesenchymal cells. Xenograft and allograft transplantation of cultured cells produced MPD lesions in the recipients. The data suggest that SRV‐2 plays an important role in the etiopathogenesis of MPD in macaques.