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Comparative Biology of Natural and Experimental SIVmac Infection in Macaque Monkeys: A Review
Author(s) -
King Norval W.,
Chalifoux Laura V.,
Ringler Douglas J.,
Wyand Michael S.,
Sehgal Prabhat K.,
Daniel Muthiah D.,
Letvin Norman L.,
Desrosiers Ronald C.,
Blake Beverly J.,
Hunt Ronald D.
Publication year - 1990
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1990.tb00418.x
Subject(s) - macaque , rhesus macaque , biology , incidence (geometry) , nonhuman primate , immunology , virology , simian immunodeficiency virus , physiology , immune system , neuroscience , evolutionary biology , physics , optics
Epidemiologic and clinicopathologic data from 11 macaques with naturally acquired SIV infection—10 of which have died—were compared with those from 34 rhesus monkeys that have died of experimental SIVmac infection. Several differences, including gender affected, age at time of death, and the occurrence of certain opportunistic infections, could be explained by the experimental design; others remained unexplained. The most striking difference was the 41% incidence of meningoencephalomyelitis in the experimental group and its absence in naturally SIV‐infected animals.