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Nonhuman Primates and Teratological Research
Author(s) -
Hendrickx A.G.,
Binkerd P.E.
Publication year - 1990
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1990.tb00417.x
Subject(s) - nonhuman primate , teratology , developmental toxicity , thalidomide , biology , animal testing , animal model , toxicity , pregnancy , physiology , toxicology , medicine , fetus , immunology , evolutionary biology , ecology , endocrinology , genetics , multiple myeloma
Nonhuman primates were first recognized as models for the study of developmental toxicity (teratology) following the thalidomide tragedy. Since that time they have played important roles in both testing of drugs for human safety and as models for studying specific malformations commonly seen in children. Although in vitro and alternative test systems using lower animal forms or simplified test systems have been incorporated into developmental toxicity studies, whole animal testing will be required for the foreseeable future because of the complex relationship of the maternal/embryofetal/placental unit. The nonhuman primate will be particularly valuable where equivocal results arc experienced in other commonly used laboratory species, when the drug/chemical is likely to be used during pregnancy, and for human‐derived biotechnical products which often arc not bioactive in nonprimate species.