Premium
Carbon Monoxide Excretion as an Index of Bilirubin Production in Rhesus Monkeys
Author(s) -
Vreman Hendrik J.,
Rodgers Pamela A.,
Gale Rena,
Stevenson David K.
Publication year - 1989
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1989.tb00412.x
Subject(s) - carboxyhemoglobin , bilirubin , excretion , protoporphyrin , heme , medicine , hemoglobin , endocrinology , carbon monoxide , physiology , chemistry , biochemistry , porphyrin , enzyme , catalysis
The role of increased heme catabolism in neonatal hyperbilirubinemia was investigated in rhesus (Macaca mulatta) neonates through the measurement of carbon monoxide excretion rates (VECO), blood carboxyhemoglobin content (HbCO), and plasma bilirubin concentrations. Neonatal values were compared to those of adult rhesus monkeys. These indices of bilirubin production responded appropriately to administration of NEM‐damaged erythrocytes and tin protoporphyrin. Our results indicate that VECO measurements are a valid index of changes in bilirubin production in the newborn rhesus monkey.