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Gonadotropin‐Releasing Hormone Infusion Interval: Importance in Pharmacodynamics
Author(s) -
Schmutzler Rita,
ElkindHirsch Karen,
Hahn Do Won,
McGuire J.L.,
Simon James A.,
Danforth Douglas R.,
Hodgen Gary D.
Publication year - 1989
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1989.tb00241.x
Subject(s) - pharmacodynamics , gonadotropin releasing hormone , medicine , hormone , pharmacology , endocrinology , pharmacokinetics , luteinizing hormone
Circulating gonadotropin‐releasing hormone (GnRH) levels were measured during and after intravenous infusion intervals ranging from 0.08 minutes to 5 minutes and doses ranging from 1 to 25 μg per pulse. In all dose groups (1 vs. 5 vs. 25 μg), the peak levels of GnRH decreased from the 0.08 minute to the 5 minute infusion interval. Our results suggest that the infusion interval over which GnRH is administered has profound effects on the amount, duration, and pattern of GnRH measured in the peripheral circulation.