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Proliferative T‐Cell Response to HIV Envelope Glycoprotein in Immunized and Infected Primates and Human Beings
Author(s) -
Krohn Kai,
Ranki Annamari,
Lusso Paolo,
Moss Bernard,
Ashorn Per,
Arthur Larry O.,
Putney Scott D.,
Gallo Robert C.
Publication year - 1989
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1989.tb00239.x
Subject(s) - virology , glycoprotein , immunology , biology , epitope , t cell , human immunodeficiency virus (hiv) , antibody , lymphokine , immune system , microbiology and biotechnology
Human immunodeficiency virus (HIV)‐specific helper T‐cell response was studied in human subjects and nonhuman primates either infected with HIV or immunized with different HIV protein preparations. A strong group‐specific T‐cell response involving T‐cell proliferation and lymphokine secretion was observed in immunized chimpanzees and rhesus monkeys as well as HIV‐infected chimpanzees and gibbons. HIV‐infected people demonstrated a low or no HIV‐specific T‐cell response. In contrast, five of 14 HIV antibody‐negative sexual partners of HIV‐infected men recognized one or more T‐cell epitopes in the envelope glycoprotein of HIV.