Premium
Postexposure Immunotherapy of Simian Immunodeficiency Virus (SIV) Infected Rhesus With an SIV Immunogen
Author(s) -
Gardner Murray B.,
Jennings Myra,
Carlson James R.,
Lerche Nicholas,
McGraw Thomas,
Luciw Paul,
Marx Preston,
Pedersen Niels
Publication year - 1989
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1989.tb00234.x
Subject(s) - simian immunodeficiency virus , immunogen , virology , simian , immunodeficiency , human immunodeficiency virus (hiv) , immunotherapy , biology , virus , immunology , immune system , antibody , monoclonal antibody
An inactivated whole simian immunodeficiency virus (SIV) immunogen given to healthy, seropositive rhesus macaques 4 months after infection had no effect on the humoral immune response to SIV, the presence of antigenemia, cell‐associated viremia, or disease course. Further immunotherapeutic trials in this highly susceptible animal model should be carried out sooner after exposure, before significant loss of CD4 cells has occurred. The SIV infected macaque model will continue to serve an essential role in development and testing of anti‐AIDS drugs and immunogens.