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Molecular Characterization and Comparison of Simian Immunodeficiency Virus Isolates From Macaques, Mangabeys, and African Green Monkeys
Author(s) -
Benveniste R.E.,
Raben D.,
Hill R.W.,
Knott W.B.,
Drummond J.E.,
Arthur L.O.,
Jahrling P.B.,
Morton W.R.,
Henderson L.E.,
Heidecker G.
Publication year - 1989
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1989.tb00231.x
Subject(s) - simian immunodeficiency virus , virology , biology , african green monkey , virus , clone (java method) , antibody , simian , immune system , cercopithecus aethiops , primate , immunology , gene , genetics , neuroscience
Simian immunodeficiency virus (SIV)/Mne has been inoculated into three species of macaques and into baboons. Virus was isolated from all the macaques who subsequently died at 15 to 120 weeks (mean 80 weeks) with various manifestations of immune deficiency. Individual animals varied in their viral antibody profile as a function of time after infection. Independent SIV isolates obtained from African green monkeys and magabeys were compared to SIV/Mne for their ability to replicate in lymphocytes and macrophages and with respect to the immunological relatedness of their viral proteins. Antibodies present in human immunodeficiency virus‐2 (HIV‐2)‐infected individuals were readily detected by the virus produced by a single‐cell clone of SIV/Mne.