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Infection of Macaque Monkeys With Simian Immunodeficiency Virus From African Green Monkeys: Virulence and Activation of Latent Infection
Author(s) -
Gravell Maneth,
London William T.,
Hamilton Rebecca S.,
Stone Gary,
Monzon Marta
Publication year - 1989
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1989.tb00226.x
Subject(s) - simian immunodeficiency virus , african green monkey , macaque , virology , cercopithecus aethiops , virulence , biology , rhesus macaque , virus , human immunodeficiency virus (hiv) , simian , haplorhini , gene , genetics , ecology
The virulence of three isolates of simian immunodeficiency virus from African green monkeys (SIV agm ) was studied in rhesus and pigtailed macaques. None of 15 rhesus monkeys and one of four pigtailed monkeys died from infection during the time they were studied (up to 33 months). SIV agm was only isolated from rhesus monkeys for up to 2 months after inoculation. However, when these animals were secondarily infected with Simian acquired immunodeficiency syndrome retrovirus type 1 (SRV‐1), SIV agm was activated and isolated. Dual infection caused increased mortality.