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Transmission of the Simian Immunodeficiency Virus SIV mne in Macaques and Baboons
Author(s) -
Morton W.R.,
Kuller L.,
Benveniste R.E.,
Clark E.A.,
Tsai C.C.,
Gale M.J.,
Thouless M.E.,
Overbaugh J.,
Katze M.G.
Publication year - 1989
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1989.tb00225.x
Subject(s) - simian immunodeficiency virus , macaque , virology , macaca nemestrina , primate , biology , transmission (telecommunications) , virus , lentivirus , simian , lymph , rhesus macaque , baboon , lymph node , immunology , viral disease , medicine , pathology , paleontology , neuroscience , endocrinology , electrical engineering , engineering
A primate lymphotropic lentivirus was isolated on Hut 78 cells after cocultivation of a lymph node from a macaque that died with malignant lymphoma. In earlier studies SIV/Mne was inoculated into 17 macaques and two baboons. All of the macaques became viremic and seropositive. Fifteen of the macaques succumbed to a classic AIDS‐like disease, whereas the baboons did not become viremic. The SIV/Mne virus has now been molecularly cloned and inoculated into Macaca nemestrina and baboons. A new transmission study has been initiated to test the effects of route and dosage on disease.