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Subcutaneous Implantable Infusion Device for Chronic Intravenous Pulsatile Gonadotropin‐Releasing Hormone Treatment
Author(s) -
Schmutzler Rita,
Uem Jan F.H.M.,
ElkindHirsch Karen,
Hahn DoWon,
McGuire J.L.,
Danforth Douglas R.,
Hodgen Gary D.
Publication year - 1988
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1988.tb00390.x
Subject(s) - pulsatile flow , medicine , gonadotropin , hormone , subcutaneous injection , gonadotropin releasing hormone , anesthesia , endocrinology , luteinizing hormone
Preliminary data indicate the potential utility of an implantable subcutaneous device that facilitates chronic intravenous infusion of pulsatile gonadotropin‐releasing hormone (GnRH) for ovulation induction. GnRH distribution curves were congruent in control monkeys and those with implanted devices. Tissue tolerance was good in this brief trial. These findings suggest that use of this or a similar implantable device be considered for chronic GnRH administration in human pulse therapy.