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Comparative Teratogenicity of Triamcinolone Acetonide and Dexamethasone in the Rhesus Monkey ( Macaca mulatta )
Author(s) -
Jerome C.P.,
Hendrickx A.G.
Publication year - 1988
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1988.tb00381.x
Subject(s) - dexamethasone sodium phosphate , triamcinolone acetonide , dexamethasone , endocrinology , fetus , gestation , glucocorticoid , medicine , encephalocele , corticosteroid , biology , pregnancy , anatomy , surgery , genetics
Pregnant rhesus macaques were treated with 0.5 or 2.5 mg/kg triamcinolone acetonide (TAC) or 1.0 or 10.0 mg/kg dexamethasone sodium phosphate (DEX) between 20 and 50 gestational days (GD). Treatment with TAC at 2.5 mg/kg resulted in a fetal loss of ≷ 71%; 3/5 recovered fetuses displayed an encephalocele or meningocele. All other treatment groups displayed minor cranial skeletal abnormalities consistent with glucocorticoid‐mediated teratogenesis. DEX was shown to have a lower teratogenic potential than TAC in this species.