Premium
Spontaneous and Experimental Hepatitis A in Old World Monkeys
Author(s) -
Shevtsova Z.V.,
Lapin B.A.,
Doroshenko N.V.,
Krilova R.I.,
Korzaja L.I.,
Lomovskaya I.B.,
Dzhelieva Z.N.,
Zairov G.K.,
Stakhanova V.M.,
Belova E.G.,
Sazhchenko L.A.
Publication year - 1988
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1988.tb00380.x
Subject(s) - virology , hepatitis , biology , physiology , medicine
Virologic, serologic, biochemical, and morphological data characterizing spontaneous hepatitis A (HA) in cynomolgus macaques ( Macaca fascicularis ) and green monkeys ( Cercopithecus aethiops ) are reported. Experimental HA was induced in macaques as a result of infection with human hepatitis A virus (HAV‐h). Disease similar to human HA was induced in cynomolgus macaques by HAV isolates from spontaneously sick rhesus ( M. mulatta ) and green monkeys. This experimental model of HA in macaques can be used for vaccine and anti‐viral preparation testing.