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Occurrence of Spontaneous Diabetes Mellitus in a Cynomolgus Monkey ( Macaca fascicularis ) and Impaired Glucose Tolerance in Its Descendants
Author(s) -
Yasuda Mitsuya,
Takaoka Masaya,
Fujiwara Toshibiko,
Mori Masahiro
Publication year - 1988
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1988.tb00196.x
Subject(s) - impaired glucose tolerance , diabetes mellitus , pathological , medicine , endocrinology , insulin , glucose tolerance test , insulin response , biology , insulin resistance , plasma glucose
Spontaneous diabetes mellitus was diagnosed in a cynomolgus monkey. Clinical and pathological features, such as abnormal glucose tolerance, loss of insuin response, or degeneration of pancreatic β‐cells, resemble human noninsulin‐dependent diabetes mellitus. Two descendants of the monkey have developed impaired glucose tolerance and insulin response. Genetic factors seem involved in the appearance of carbohydrate intolerance in this family group of monkeys.