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Hemodynamic and Echocardiographic Evaluation of the Stumptailed Macaque: A Potential Nonhuman Primate Model for Pulmonary Vascular Disease
Author(s) -
Weesner Kenneth M.,
Kaplan Katherine
Publication year - 1987
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1987.tb00328.x
Subject(s) - pulmonary artery , hemodynamics , pulmonary hypertension , medicine , cardiology , macaque , rhesus macaque , cardiac catheterization , biology , paleontology , immunology
Stumptailed macaques ( Macaca arctoides ) were evaluated as to their suitability as an animal model for pulmonary hypertension. Animals used for this study were colony‐bred. Necropsy material from 63 animals revealed 32% with severe medial thickening of pulmonary arteries. Twenty‐nine stumptailed macaques underwent cardiac catheterization and M‐mode echocardiography. Hemodynamic measurement including pulmonary artery pressure response to 12% oxygen exposure identified three groups of animals with elevated, normal, and intermediate pulmonary artery pressures. Stumptailed macaques with elevated pulmonary artery pressure could be distinguished from other animals by echocardiography.