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Experimental Argentine Hemorrhagic Fever: Myocardial Involvement in Cebus Monkey
Author(s) -
Oubiña José R.,
Milei José,
Bolomo Narciso J.,
Molindo Alfredo,
Carballal Guadalupe
Publication year - 1986
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1986.tb00303.x
Subject(s) - clone (java method) , pathology , biology , virus , virology , medicine , dna , genetics
Four Cebus apella monkeys, to test a recently proposed model for testing neurovirulence of Junín virus (JV) strains, were intracerebrally infected with 10 5 LD 50 of the XJ clone 3 strain of JV. There were no significant electrocardiographic abnormalities or gross lesions, but all infected monkeys exhibited a varying degree of histologic myocardial lesions including focal lymphoblastic infiltrates, vascular ruptures, and mild interstitial reactive change. One Cebus showed lymphocytic infiltrates in the caudal portion of the A‐V node without specific cell involvement. These preliminary results demonstrate cardiac involvement in experimental infection of the Cebus monkey with Junín virus.