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Host Defense Deficiency in Newborn Nonhuman Primate Lungs
Author(s) -
Cheung Anthony T.W.,
Kurland Geoffrey,
Miller Michael E.,
Ford Elizabeth W.,
Ayin Susan A.,
Walsh Erin M.
Publication year - 1986
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1986.tb00189.x
Subject(s) - nonhuman primate , biology , host (biology) , primate , physiology , zoology , immunology , evolutionary biology , neuroscience , ecology
We have investigated two major aspects of the pulmonary host defense mechanism—alveolar macrophage function as a “first line of bacterial defense” and induced neutrophil migration into the lung as a “back‐up defense.” Chemotactic and phagocytic/killing assays revealed a functional deficiency in the alveolar macrophages of newborn primates. Serial bronchoalveolar lavage investigations revealed diminished neutrophil migration into the newborn primate lung. The overall pulmonary host defense capability in newborn primates was deficient. The results of this investigation may have direct clinical relevance to the susceptibility of newborns to infections and pneumonia.