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Monitoring Ovulation and Implantation in the Cynomolgus Macaque (Macaca fascicularis) Through Evaluations of Urinary Estrone Conjugates and Progesterone Metabolites: A Technique for the Routine Evaluation of Reproductive Parameters
Author(s) -
Monfort S.L.,
Jayaraman S.,
Shideler S.E.,
Lasley B.L.,
Hendrickx A.G.
Publication year - 1986
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1986.tb00187.x
Subject(s) - estrone , macaque , ovulation , luteal phase , estrogen , endocrinology , medicine , radioimmunoassay , urinary system , conjugate , ovariectomized rat , pregnancy , ovary , biology , chemistry , hormone , paleontology , mathematical analysis , genetics , mathematics
Investigations were undertaken to determine the applicability of recently reported specific radioimmunoassays for urinary estrone conjugates and progesterone metabolites for monitoring ovarian function in the cynomolgus macaque ( Macaca fasciularis) and other macaque species. Mean estrone conjugate measurements appear to accurately reflect the preovulatory estrogen peak in both conceptive (n = 5) and nonconceptive (n = 6) cycles, as well as to indicate early pregnancy through increases which are significantly elevated by Day + 15 (p < 0.049) post estrone conjugates peak. The mean luteal phase levels of these progesterone metabolites are significantly elevated by Day + 14 (p < 0.012) in conceptive cycles when compared to the mean values for nonconceptive cycles.