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Studies of Sub‐human Primate (Marmoset) Pluripotent Hemopoietic Stem Cells (CFU‐GEMM) In Vitro
Author(s) -
Michalevicz R.,
Hetherington C.M.,
Hann I.,
Blacklock H.A.
Publication year - 1985
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1985.tb00261.x
Subject(s) - marmoset , primate , biology , haematopoiesis , in vitro , callithrix , induced pluripotent stem cell , stem cell , non human primate , microbiology and biotechnology , evolutionary biology , embryonic stem cell , neuroscience , genetics , gene , paleontology
Pluripotent hemopoietic progenitor cells (CFU‐GEMM) grow in vitro from marmoset bone marrow using a modified human CFU‐GEMM assay. Characteristics of growth are similar to those reported in the human CFU‐GEMM assay. The number of CFU‐GEMM/10 5 marrow cells from marmoset bone marrow is approximately four times that grown in human marrow in our laboratory. Data concerning EPO and other requirements for growth of CFU‐GEMM demonstrate an assay for the pluripotent hemopoietic progenitor in the marmoset. This assay may be useful in designing preclinical primate bone marrow transplant experiments.