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Gestational Diabetes Mellitus and Impaired Glucose Tolerance in an Aged Macaca mulatta
Author(s) -
Kessler Matt J.,
Howard Charles F.,
London William T.
Publication year - 1985
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1985.tb00260.x
Subject(s) - medicine , gestational diabetes , impaired glucose tolerance , endocrinology , glucose tolerance test , diabetes mellitus , insulin , gestation , overweight , fetus , pregnancy , physiology , obesity , type 2 diabetes , insulin resistance , biology , genetics
Gestational diabetes mellitus was diagnosed in an aged (21‐year‐old) pregnant rhesus monkey ( Macaca mulatto ); she was hyperglycemic and had minimal glucose clearance in an intravenous glucose tolerance test (iv‐GTT). An overweight (840 g) dead full‐term fetus was delivered by cesarean section. A second iv‐GTT conducted 3 months later revealed impaired glucose tolerance. While pregnant, the monkey was hypcrinsulinemic and showed minimal secretory response to the glucose load. When tested postpartum, the fasting insulin was only slightly elevated, but the insulin response to glucose was still lacking.