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Characterization of a Gilbert‐Like Syndrome in Squirrel Monkeys (Saimiri sciureus)
Author(s) -
Cornelius Charles E.,
Rodgers Pamela A.,
Bruss Michael L.,
Ahlfors Charles E.
Publication year - 1985
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1985.tb00172.x
Subject(s) - saimiri sciureus , squirrel monkey , endocrinology , tolbutamide , phenobarbital , medicine , indocyanine green , biology , pathology , anatomy , insulin
Bolivian squirrel monkeys, unlike those of Brazilian origin, exhibit a marked fasting hyperbilirubinemia (FH) similar to that observed in Gilbert's syndrome in man. Since no delays in the hepatic clearance of sulfobromophthalein or indocyanine green arc present, the Bolivian monkey appears to be similar to Gilbert's type I syndrome. FH can be significantly decreased by either phenobarbital or tin‐protoporphyrin pretrealment. Nicotinic acid‐induced hyperbilirubinemia and delayed tolbutamide clearance were not observed as in the human syndrome.