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Response of Monkeys to Porcine Zona Pellucida as Detected by a Solid‐Phase Radioimmunoassay
Author(s) -
Gulyas Bela J.,
Yuan Lydia C.,
Gwatkin R.B.L.,
Schmell Eli D.
Publication year - 1983
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1983.tb00097.x
Subject(s) - zona pellucida , titer , radioimmunoassay , antibody , immunization , serial dilution , antibody titer , immunology , biology , antibody response , andrology , virology , medicine , endocrinology , pathology , oocyte , embryo , alternative medicine , microbiology and biotechnology
The immunological response of cynomolgus monkeys {Macaca fascicularis) to immunization was evaluated utilizing collagcnase‐isolated pig zona pellucida. Six weeks after initial immunization a high serum titer of antibody was exhibited. Serum antibody titers demonstrated a noticeable decline 5 months after booster injections were discontinued. The assay method used is rapid and is capable of detecting antibody in serum dilutions of 1:78,000, as compared to 1:125,000 with the indirect fluorescence assay.