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Nitric oxide in exhaled and aspirated nasal air as an objective measure of human response to indoor air pollution
Author(s) -
Kolarik B.,
Lagercrantz L.,
Sundell J.
Publication year - 2009
Publication title -
indoor air
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.387
H-Index - 99
eISSN - 1600-0668
pISSN - 0905-6947
DOI - 10.1111/j.1600-0668.2008.00572.x
Subject(s) - exhaled nitric oxide , nitric oxide , environmental chemistry , exhaled air , pollutant , indoor air , expired air , environmental science , air pollutants , air pollution , medicine , chemistry , toxicology , inflammation , systemic inflammation , environmental engineering , immunology , biology , organic chemistry
The concentration of nitric oxide (NO) in exhaled and aspirated nasal air was used to objectively assess human response to indoor air pollutants in a climate chamber exposure experiment. The concentration of NO was measured before exposure, after 2, and 4.5 h of exposure, using a chemiluminescence NO analyzer. Sixteen healthy female subjects were exposed to two indoor air pollutants and to a clean reference condition for 4.5 h. Subjective assessments of the environment were obtained by questionnaires. After exposure (4.5 h) to the two polluted conditions a small increase in NO concentration in exhaled air was observed. After exposure to the reference condition the mean NO concentration was significantly reduced compared to pre-exposure. Together these changes resulted in significant differences in exhaled NO between exposure to reference and polluted conditions. NO in nasal air was not affected by the exposures. The results may indicate an association between polluted indoor air and subclinical inflammation.