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S1PR2 links germinal center confinement and growth regulation
Author(s) -
Green Jesse A.,
Cyster Jason G.
Publication year - 2012
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2012.01114.x
Subject(s) - germinal center , biology , context (archaeology) , microbiology and biotechnology , cell growth , somatic cell , b cell , immunology , genetics , gene , paleontology , antibody
Summary: Germinal centers (GCs) are sites of rapid B‐cell proliferation and somatic mutation. These ovoid structures develop within the center of follicles and grow to a stereotypic size. The cell migration and interaction dynamics underlying GC B‐cell selection events are currently under intense scrutiny. In recent study, we identified a role for a migration inhibitory receptor, S1PR2, in promoting GC B‐cell confinement to GCs. S1PR2 also dampens Akt activation and deficiency in S1PR2 or components of its signaling pathway result in a loss of growth control in chronically stimulated mucosal GCs. Herein, we detail present understanding of S1PR2 and S1P biology as it pertains to GC B cells and place this information in the context of a current model of GC function.