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NF‐κB regulation: lessons from structures
Author(s) -
Ghosh Gourisankar,
Wang Vivien YaFan,
Huang DeBin,
Fusco Amanda
Publication year - 2012
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2012.01097.x
Subject(s) - iκb kinase , nf κb , microbiology and biotechnology , biology , signal transduction , nfkb1 , kinase , gene , computational biology , transcription factor , genetics
Summary: The signaling module that specifies nuclear factor‐κΒ (NF‐κB) activation is a three‐component system: NF‐κB, inhibitor of NF‐κΒ (IκΒ), and IκΒ kinase complex (IKK). IKK receives upstream signals from the surface or inside the cell and converts itself into a catalytically active form, leading to the destruction of IκB in the inhibited IκB:NF‐κB complex, leaving active NF‐κB free to regulate target genes. Hidden within this simple module are family members that all can undergo various modifications resulting in expansion of functional spectrum. Three‐dimensional structures representing all three components are now available. These structures have allowed us to interpret cellular observations in molecular terms and at the same time helped us to bring forward new concepts focused towards understanding the specificity in the NF‐κB activation pathway.