Premium
Dynamic roles for NF‐κB in HTLV‐I and HIV‐1 retroviral pathogenesis
Author(s) -
Chan Jonathan K.,
Greene Warner C.
Publication year - 2012
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2012.01094.x
Subject(s) - biology , virology , virus , immune system , viral replication , innate immune system , human immunodeficiency virus (hiv) , immunology , transcription factor , arms race , pathogenesis , gene , genetics , history , economic history
Summary: Viruses and hosts are involved in a continuing ‘arms race’. The body deploys multiple defenses; however, viruses utilize generally superior and more rapidly evolving tactics for negating host immune surveillance and viral clearance. In the case of the two major pathogenic human retroviruses, human immunodeficiency virus‐1 (HIV‐1) and human T‐lymphotrophic virus‐I (HTLV‐I), the nuclear factor‐κB (NF‐κB) transcription factor plays a key role in the host’s anti‐viral responses involving both the innate and adaptive arms of the immune response. Similarly, these retroviruses capably exploit NF‐κB for their replication, spread, and pathogenic functions. In this review, we discuss the dynamic and intimate interplay that occurs between NF‐κB and the HTLV‐I and HIV‐1 retroviral pathogens.