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Development and evolution of RORγt + cells in a microbe’s world
Author(s) -
Eberl Gérard
Publication year - 2012
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2011.01071.x
Subject(s) - rar related orphan receptor gamma , innate lymphoid cell , biology , orphan receptor , nuclear receptor , microbiology and biotechnology , immunology , tumor necrosis factor alpha , immune system , innate immune system , transcription factor , foxp3 , genetics , gene
Summary: The nuclear hormone receptor retinoid‐related orphan receptor γt (RORγt) induces a pro‐inflammatory program in lymphoid cells, culminating in the expression of interleukin‐6 (IL‐6), IL‐17, IL‐22, granulocyte‐macrophage colony‐stimulating factor, and tumor necrosis factor. During ontogeny, the first type of cells expressing RORγt are lymphoid tissue inducer cells, a type of innate lymphoid cell (ILC) generated in mammalian fetuses to induce the development of lymph nodes and Peyer’s patches. After birth, RORγt + ILCs and RORγt + T cells are involved in the defense of epithelial surfaces against extracellular microbes and play an important role in the intestinal homeostasis with symbiotic microbiota. The development and evolution of RORγt + cells is intimately associated with the construction of a stable host–microbe interface.