Premium
Regulatory T cells and Foxp3
Author(s) -
Rudensky Alexander Y.
Publication year - 2011
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2011.01018.x
Subject(s) - foxp3 , immune system , biology , immunology , function (biology) , homeostasis , transcription factor , gene , microbiology and biotechnology , genetics
Summary: Regulatory T (Treg) cells play central role in regulation of immune responses to self‐antigens, allergens, and commensal microbiota as well as immune responses to infectious agents and tumors. Transcriptional factor Foxp3 serves as a lineage specification factor of Treg cells. Paucity of Treg cells due to loss‐of‐function mutations of the Foxp3 gene is responsible for highly aggressive, fatal, systemic immune‐mediated inflammatory lesions in mice and humans. Recent studies of Foxp3 expression and function provided critical novel insights into biology of Treg cells and into cellular mechanisms of the immune homeostasis.