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Cell biology and immunology of Listeria monocytogenes infections: novel insights
Author(s) -
Stavru Fabrizia,
Archambaud Cristel,
Cossart Pascale
Publication year - 2011
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2010.00993.x
Subject(s) - listeria monocytogenes , biology , intracellular parasite , immune system , listeria infection , intracellular , immunology , listeria , microbiology and biotechnology , bacteria , acquired immune system , immunity , innate immune system , virology , genetics
Summary: Listeria monocytogenes is an intracellular bacterium responsible for a disease characterized by several clinical features, such as septicemia, brain infection, abortion, and perinatal infection. These clinical features are attributed to its amazing capacity to cross several barriers in susceptible hosts. Intracellular infection is a consequence of the bacterium’s capacity to enter a wide variety of mammalian cells, to not only survive but also replicate therein, and to its faculty to spread from one cell to the next, thereby escaping the humoral immune response. Here, we review both the well‐established and the newly discovered strategies used by this bacterium to achieve this intracellular lifestyle while escaping from the host innate immune response. More than ever, Listeria appears as a model system and a reference in infection biology.