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Innate immunity to intracellular pathogens: macrophage receptors and responses to microbial entry
Author(s) -
Plüddemann Annette,
Mukhopadhyay Subhankar,
Gordon Siamon
Publication year - 2011
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2010.00989.x
Subject(s) - biology , innate immune system , macrophage , effector , context (archaeology) , immunity , immunology , receptor , intracellular , intracellular parasite , microbiology and biotechnology , immune system , in vitro , genetics , paleontology
Summary: Innate immunity to intracellular pathogens encompasses a range of interactions of cellular and humoral activities of the host with the invading microorganism, determining the outcome of infection. Here, we review the particular role of macrophage recognition receptors and effector responses in the uptake of microbes and their products. We place this in context and raise issues for discussion and further experimentation.