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Unique properties of memory B cells of different isotypes
Author(s) -
Kurosaki Tomohiro,
Aiba Yuichi,
Kometani Kohei,
Moriyama Saya,
Takahashi Yoshimasa
Publication year - 2010
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2010.00939.x
Subject(s) - isotype , biology , immunoglobulin class switching , germinal center , memory b cell , antigen , antibody , b cell , immunology , naive b cell , b 1 cell , effector , b cell receptor , microbiology and biotechnology , t cell , antigen presenting cell , immune system , monoclonal antibody
Summary: Memory antibody responses are typically seen to T‐cell‐dependent antigens and are characterized by the rapid production of high titers of high‐affinity antigen‐specific antibody. The hallmark of T‐cell‐dependent memory B cells is their expression of a somatically mutated, isotype‐switched B‐cell antigen receptor, features that are mainly generated in germinal centers. Classical studies have focused on isotype‐switched memory B cells (mainly IgG isotype) and demonstrated their unique intrinsic properties in terms of localization and responsiveness to antigen re‐exposure. However, recent advances in monitoring antigen‐experienced B cells have revealed the considerable heterogeneity of memory B cells, which include unswitched IgM + and/or unmutated memory B cells. The IgM and IgG type memory B cells reside in distinct locations and appear to possess distinct origins and effector functions, together orchestrating humoral memory responses.