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Generation of effector CD8 + T cells and their conversion to memory T cells
Author(s) -
Cui Weiguo,
Kaech Susan M.
Publication year - 2010
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2010.00926.x
Subject(s) - effector , biology , immunological memory , cd8 , microbiology and biotechnology , cytotoxic t cell , acquired immune system , immunology , neuroscience , immunity , immune system , genetics , in vitro
Summary: Immunological memory is a cardinal feature of adaptive immunity. We are now beginning to elucidate the mechanisms that govern the formation of memory T cells and their ability to acquire longevity, survive the effector‐to‐memory transition, and mature into multipotent, functional memory T cells that self‐renew. Here, we discuss the recent findings in this area and highlight extrinsic and intrinsic factors that regulate the cellular fate of activated CD8 + T cells.