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Targeting granulocyte apoptosis: mechanisms, models, and therapies
Author(s) -
Duffin Rodger,
Leitch Andrew E.,
Fox Sarah,
Haslett Chris,
Rossi Adriano G.
Publication year - 2010
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2010.00922.x
Subject(s) - efferocytosis , granulocyte , inflammation , biology , phagocytosis , immunology , apoptosis , bone marrow , macrophage , haematopoiesis , immune system , microbiology and biotechnology , stem cell , in vitro , biochemistry
Summary: The inflammatory process is a complex series of tightly controlled cellular and biochemical events initiated by the immune system, which has evolved to eliminate or contain infectious agents and to repair damaged tissue. Apoptosis is essential for the clearance of potentially injurious inflammatory cells, such as neutrophils, eosinophils, and basophils, and the subsequent efficient resolution of inflammation. In this review, we aim to cover key features of the granulocyte life‐cycle ranging from their differentiation within the bone marrow to their maturation and ultimate clearance, with a focus on granulocyte apoptosis and macrophage efferocytosis. We further aim to discuss current and emerging models of inflammation and suggest novel ways of terminating or resolving deleterious inflammatory responses with a specific view to the translation of these strategies into fully realized, pro‐resolution therapies.