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The T‐cell‐specific adapter protein family: TSAd, ALX, and SH2D4A/SH2D4B
Author(s) -
Lapinski Philip E.,
Oliver Jennifer A.,
Bodie Jennifer N.,
Marti Francesc,
King Philip D.
Publication year - 2009
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2009.00829.x
Subject(s) - signal transducing adaptor protein , adapter (computing) , signal transduction , biology , microbiology and biotechnology , function (biology) , t cell receptor , t cell , genetics , immune system , electrical engineering , engineering
Summary: Adapter proteins play key roles in intracellular signal transduction through complex formation with catalytically active signaling molecules. In T lymphocytes, the role of several different types of adapter proteins in T‐cell antigen receptor signal transduction is well established. An exception to this is the family of T‐cell‐specific adapter (TSAd) proteins comprising of TSAd, adapter protein of unknown function (ALX), SH2D4A, and SH2D4B. Only recently has the function of these adapters in T‐cell signal transduction been explored. Here, we discuss advances in our understanding of the role of this family of adapter proteins in T cells. Their function as regulators of signal transduction in other cell types is also discussed.