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Capacitative calcium entry: from concept to molecules
Author(s) -
Putney James W.
Publication year - 2009
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2009.00810.x
Subject(s) - endoplasmic reticulum , intracellular , microbiology and biotechnology , inositol , second messenger system , effector , calcium signaling , stim1 , activator (genetics) , calcium , biology , plasma membrane ca2+ atpase , chemistry , biophysics , receptor , biochemistry , enzyme , atpase , organic chemistry
Summary: Rapid to moderately rapid changes in intracellular Ca 2+ concentration, or Ca 2+ signals, control a variety of critical cellular functions in the immune system. These signals are comprised of Ca 2+ release from intracellular stores coordinated with Ca 2+ influx across the plasma membrane. The most common mechanisms by which these two modes of signaling occur is through inositol 1,4,5‐trisphosphate (IP 3 )‐induced release of Ca 2+ from the endoplasmic reticulum (ER) and store‐operated Ca 2+ entry across the plasma membrane. The latter process was postulated over 20 years ago, and in just the past few years, the key molecular players have been discovered: STIM proteins serve as sensors of Ca 2+ within the ER which communicate with and activate plasma membrane store‐operated channels composed of Orai subunits. The process of store‐operated Ca 2+ entry provides support for oscillating Ca 2+ signals from the ER and also provides direct activator Ca 2+ that signals to a variety of downstream effectors.