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Endogenous ligands for C‐type lectin receptors: the true regulators of immune homeostasis
Author(s) -
GarcíaVallejo Juan J.,
Van Kooyk Yvette
Publication year - 2009
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2009.00786.x
Subject(s) - c type lectin , biology , endogeny , immune system , homeostasis , receptor , lectin , immunology , microbiology and biotechnology , immune receptor , genetics , biochemistry
Summary: C‐type lectin receptors (CLRs) have long been known as pattern‐recognition receptors implicated in the recognition of pathogens by the innate immune system. However, evidence is accumulating that many CLRs are also able to recognize endogenous ‘self’ ligands and that this recognition event often plays an important role in immune homeostasis. In the present review, we focus on the human and mouse CLRs for which endogenous ligands have been described. Special attention is given to the signaling events initiated upon recognition of the self ligand and the regulation of glycosylation as a switch modulating CLR recognition, and therefore, immune homeostasis.