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Function of Nod‐like receptors in microbial recognition and host defense
Author(s) -
Franchi Luigi,
Warner Neil,
Viani Kyle,
Nuñez Gabriel
Publication year - 2009
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2008.00734.x
Subject(s) - biology , host (biology) , nod , receptor , function (biology) , pattern recognition receptor , immunology , computational biology , microbiology and biotechnology , genetics , gene , innate immune system
Summary: Nucleotide oligomerization domain (NOD)‐like receptors (NLRs) are a specialized group of intracellular proteins that play a critical role in the regulation of the host innate immune response. NLRs act as scaffolding proteins that assemble signaling platforms that trigger nuclear factor‐κB and mitogen‐activated protein kinase signaling pathways and control the activation of inflammatory caspases. Importantly, mutations in several members of the NLR family have been linked to a variety of inflammatory diseases consistent with these molecules playing an important role in host–pathogen interactions and the inflammatory response. In this review, we focus on the role of Nod1 and Nod2 in host defense and in particular discuss recent finding regarding the role of Nlrc4, Nlpr1, and Nlrp3 inflammasomes in caspase‐1 activation and subsequent release of proinflammatory cytokines such as interleukin‐1β.