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Regulation and pro‐inflammatory function of interleukin‐17 family cytokines
Author(s) -
Dong Chen
Publication year - 2008
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2008.00709.x
Subject(s) - autoimmunity , immunology , inflammation , immune system , interleukin , proinflammatory cytokine , biology , function (biology) , interleukin 20 , cytokine , interleukin 5 , microbiology and biotechnology
Summary: The interleukin‐17 (IL‐17) family consists of six cytokines in mammals. Among them, IL‐17 and IL‐17F are expressed by a novel subset of CD4 + helper T cells and play critical function in inflammation and autoimmunity. IL‐17E, also called IL‐25, has been associated with allergic responses. Here, I summarize recent work by my laboratory as well as other investigators in understanding the regulation and function of these three cytokines. From these studies, IL‐17 family cytokines may serve as novel targets for pharmaceutical intervention of immune and inflammatory diseases.