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Interleukin‐2 in the development and control of inflammatory disease
Author(s) -
Hoyer Katrina K.,
Dooms Hans,
Barron Luke,
Abbas Abul K.
Publication year - 2008
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2008.00697.x
Subject(s) - effector , biology , immunology , immune system , microbiology and biotechnology , t cell , function (biology) , cell growth , inflammation , interleukin 15 , cytokine , interleukin , cancer research , genetics
Summary: Interleukin‐2 (IL‐2) has multiple, sometimes opposing, functions during an inflammatory response. It is a potent inducer of T‐cell proliferation and T‐helper 1 (Th1) and Th2 effector T‐cell differentiation and provides T cells with a long‐lasting competitive advantage resulting in the optimal survival and function of memory cells. In a regulatory role, IL‐2 is important for the development, survival, and function of regulatory T cells, it enhances Fas‐mediated activation‐induced cell death, and it inhibits the development of inflammatory Th17 cells. Thus, in its dual and contrasting functions, IL‐2 contributes to both the induction and the termination of inflammatory immune responses.