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Hantavirus‐induced immunity in rodent reservoirs and humans
Author(s) -
Schönrich Günther,
Rang Andreas,
Lütteke Nina,
Raftery Martin J.,
Charbonnel Nathalie,
Ulrich Rainer G.
Publication year - 2008
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2008.00694.x
Subject(s) - hantavirus , hantavirus infection , hantavirus pulmonary syndrome , rodent , biology , virology , immune system , immunology , immunity , transmission (telecommunications) , innate immune system , disease reservoir , virus , ecology , electrical engineering , engineering
Summary: Hantaviruses are predominantly rodent‐borne pathogens, although recently novel shrew‐associated hantaviruses were found. Within natural reservoir hosts, hantairuses do not cause obvious pathogenetic effects; transmission to humans, however, can lead to hemorrhagic fever with renal syndrome or hantavirus cardiopulmonary syndrome, depending on the virus species involved. This review is focussed on the recent knowledge on hantavirus‐induced immune responses in rodent reservoirs and humans and their impact on susceptibility, transmission, and outcome of hantavirus infections. In addition, this review incorporates a discussion on the potential role of direct cell‐virus interactions in the pathogenesis of hantavirus infections in humans. Finally, questions for further research efforts on the immune responses in potential hantavirus reservoir hosts and humans are summarized.