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Tumor‐induced tolerance and immune suppression by myeloid derived suppressor cells
Author(s) -
Marigo Ilaria,
Dolcetti Luigi,
Serafini Paolo,
Zanovello Paola,
Bronte Vincenzo
Publication year - 2008
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2008.00602.x
Subject(s) - immune system , immune tolerance , biology , myeloid , myeloid derived suppressor cell , immunology , suppressor , tumor progression , tumor microenvironment , cancer research , cancer , genetics
Summary: Emerging evidence indicates that the Achilles' heel of cancer immunotherapies is often the complex interplay of tumor‐derived factors and deviant host properties, which involve a wide range of immune elements in the lymphoid and myeloid compartments. Regulatory lymphocytes, tumor‐conditioned myeloid‐derived suppressor cells (MDSCs), tumor‐associated macrophages, and dysfunctional and immature dendritic cells take part in a complex immunoregulatory network. Despite the fact that some mechanisms governing tumor‐induced immune tolerance and suppression are starting to be better understood and their complexity dissected, little is known about the diachronic picture of immune tolerance. Based on observations of MDSCs, we present a time‐structured and topologically consistent idea of tumor‐dependent tolerance progression in tumor‐bearing hosts.