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How human neutrophils kill and degrade microbes: an integrated view
Author(s) -
Nauseef William M.
Publication year - 2007
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2007.00550.x
Subject(s) - neutrophil extracellular traps , biology , innate immune system , immunology , myeloperoxidase , immune system , phagocyte , chemotaxis , phagocytosis , respiratory burst , granulocyte , microbiology and biotechnology , nicotinamide adenine dinucleotide phosphate , oxidase test , inflammation , receptor , enzyme , biochemistry
Summary: Neutrophils constitute the dominant cell in the circulation that mediates the earliest innate immune human responses to infection. The morbidity and mortality from infection rise dramatically in patients with quantitative or qualitative neutrophil defects, providing clinical confirmation of the important role of normal neutrophils for human health. Neutrophil‐dependent anti‐microbial activity against ingested microbes represents the collaboration of multiple agents, including those prefabricated during granulocyte development in the bone marrow and those generated de novo following neutrophil activation. Furthermore, neutrophils cooperate with extracellular agents as well as other immune cells to optimally kill and degrade invading microbes. This brief review focuses attention on two examples of the integrated nature of neutrophil‐mediated anti‐microbial action within the phagosome. The importance and complexity of myeloperoxidase‐mediated events illustrate a collaboration of anti‐microbial responses that are endogenous to the neutrophil, whereas the synergy between the phagocyte NADPH (nicotinamide adenine dinucleotide phosphate) oxidase and plasma‐derived group IIA phospholipase A 2 exemplifies the collective effects of the neutrophil with an exogenous factor to achieve degradation of ingested staphylococci.