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Collaboration between the innate immune receptors dectin‐1, TLRs, and Nods
Author(s) -
Underhill David M.
Publication year - 2007
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2007.00548.x
Subject(s) - innate immune system , biology , receptor , pattern recognition receptor , chemokine , immune system , mediator , immunology , immune receptor , nod , chemokine receptor , signal transduction , microbiology and biotechnology , computational biology , genetics , gene
Summary: Microbes are complex and present a wide variety of structures that phagocytes may recognize using innate immune receptors. Recognition triggers anti‐microbial killing mechanisms and production of inflammatory cytokines and chemokines that orchestrate host defense. As a general rule, no single receptor is likely to be the sole mediator of activation of protective immune responses. Recent studies highlight the importance of collaboration between Toll‐like receptors, the nucleotide oligomerization domain (Nod) proteins, and dectin‐1 in regulating inflammatory responses. Studies on the molecular mechanisms of cross‐talk and synergy between these receptors provide a framework in which to understand the importance of having multiple receptors recognize individual microbes.