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To activate or not to activate: distinct strategies used by Helicobacter pylori and Francisella tularensis to modulate the NADPH oxidase and survive in human neutrophils
Author(s) -
Allen LeeAnn H.,
McCaffrey Ramona L.
Publication year - 2007
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2007.00544.x
Subject(s) - francisella tularensis , biology , microbiology and biotechnology , innate immune system , nadph oxidase , nicotinamide adenine dinucleotide phosphate , tularemia , helicobacter pylori , francisella , immune system , oxidase test , phagocytosis , chemotaxis , macrophage , immunology , enzyme , receptor , reactive oxygen species , biochemistry , gene , virulence , in vitro , genetics
Summary: Neutrophils accumulate rapidly at sites of infection, and the ability of these cells to phagocytose and kill microorganisms is an essential component of the innate immune response. Relatively few microbial pathogens are able to evade neutrophil killing. Herein, we describe the novel strategies used by Helicobacter pylori and Francisella tularensis to disrupt neutrophil function, with a focus on assembly and activation of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase.