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Role of β‐chemokines in mast cell activation and type I hypersensitivity reactions in the conjunctiva: in vivo and in vitro studies
Author(s) -
Beer Frederick,
Kuo ChuanHui,
Morohoshi Kei,
Goodliffe James,
Munro Peter,
Aye Cho Cho,
Dawson Maria,
Richardson Ricardo M.,
Jones Limei H.,
Ikeda Yoshifumi,
Nakamura Takao,
Toda Masako,
Flynn Tom,
Ohbayashi Masaharu,
Miyazaki Dai,
Ono Santa Jeremy
Publication year - 2007
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2007.00521.x
Subject(s) - mast cell , chemokine , immunology , biology , microbiology and biotechnology , in vivo , priming (agriculture) , cxc chemokine receptors , in vitro , chemokine receptor , ex vivo , inflammation , biochemistry , botany , germination
Summary: Chemokines have a clearly defined role in mobilizing the recruitment of leukocytes to both healthy and inflamed tissues. This review details work from our and other laboratories, indicating that β‐chemokines may play important roles (i) in driving the terminal differentiation of mast cell precursors in mucosal tissues and (ii) in providing priming or costimulatory signals required for mast cell activation, leading to an antigen‐driven inflammatory response. These data stem from in vivo , ex vivo , and in vitro studies. Data are also presented that suggest that FcɛRI:chemokine receptor cross talk may involve spatiotemporal dynamics that may control the strength and nature of the complex activating signals controlling mast cell effector function.