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Toward a multiscale model of antigen presentation in immunity
Author(s) -
Kirschner Denise E.,
Chang Stewart T.,
Riggs Thomas W.,
Perry Nicolas,
Linderman Jennifer J.
Publication year - 2007
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2007.00490.x
Subject(s) - presentation (obstetrics) , antigen presentation , major histocompatibility complex , representation (politics) , immunology , class (philosophy) , immune system , biology , antigen processing , antigen , computer science , computational biology , cognitive science , psychology , medicine , t cell , artificial intelligence , politics , political science , law , radiology
Summary: A functioning immune system and the process of antigen presentation in particular encompass events that occur at multiple length and time scales. Despite a wealth of information in the biological literature regarding each of these scales, no single representation synthesizing this information into a model of the overall immune response as it depends on antigen presentation is available. In this article, we outline an approach for integrating information over relevant biological and temporal scales to generate such a representation for major histocompatibility complex class II‐mediated antigen presentation. In addition, we begin to address how such models can be used to answer questions about mechanisms of infection and new strategies for treatment and vaccines.